After studying Medicine at the Faculty of Medicine Paris 12, he completed an internship in neurology at the University Hospital in Limoges. He worked as a French doctor at Taez Hospital in Yemen and was Research Associate for two years at the Albert Einstein College of Medicine in New York from 1984 to 1986. During this period, he obtained a PhD in neuroscience from the University of Paris 6 on Guam's disease, associating Parkinson's disease, dementia and amyotrophic lateral sclerosis. After having been a Hospital Practitioner of Neurology for two years, he was appointed Professor of Universities in Cytology Histology at the Faculty of Medicine of Limoges in 1989 and consultant neurologist. In the late 90s, he obtained a chair in the Faculty of Medicine of the University of Hong Kong / Queen Mary Hospital/ Neurology and became Head of Department. Upon his return in 2003, he was appointed Professor at the Poitiers University Hospital and worked at the Memory Center of this hospital. Since 2006, he has been full professor at the Faculty of Medicine Paris 7 and at Lariboisière Fernand-Widal hospital and head of the department of the Center for Cognitive Neurology in this hospital for 12 years (CMRR Paris Nord Ile de France). He is an honorary professor at the University of Hong Kong. His current research interests include biomarkers and changes in the molecular signaling of neurons in Alzheimer's disease and other neurodegenerative disorders. He has authored more than 300 publications.